First- and Second-Trimester Down Syndrome Screening: Current Strategies and Clinical Guidelines
نویسندگان
چکیده
منابع مشابه
First- and second-trimester evaluation of risk for Down syndrome.
OBJECTIVE To investigate the differences in costs and outcomes of Down syndrome screening using data from the First and Second Trimester Evaluation of Risk (FASTER) Trial. METHODS Seven possible screening options for Down syndrome were compared: 1) Triple Screen-maternal serum alpha fetoprotein, estriol, and hCG; 2) Quad-maternal serum alpha fetoprotein, estriol, hCG, and Inhibin A; 3) Combin...
متن کاملScreening for Down's syndrome: effects, safety, and cost effectiveness of first and second trimester strategies.
OBJECTIVE To compare the effects, safety, and cost effectiveness of antenatal screening strategies for Down's syndrome. DESIGN Analysis of incremental cost effectiveness. SETTING United Kingdom. MAIN OUTCOME MEASURES Number of liveborn babies with Down's syndrome, miscarriages due to chorionic villus sampling or amniocentesis, health care costs of screening programme, and additional costs...
متن کاملCombining first and second trimester markers for Down syndrome screening: think twice.
AIMS This study compares different screening strategies for the detection of Down syndrome and considers practical implications of using multiple screening protocols. METHODS The performance characteristics of each screening strategy were assessed based on datasets of Down syndrome (n=11) and unaffected pregnancies (n=1006) tested in both first and second trimester, as well as data from first...
متن کاملRole of second-trimester genetic sonography after Down syndrome screening.
OBJECTIVE To estimate the effectiveness of second-trimester genetic sonography in modifying Down syndrome screening test results. METHODS The First and Second Trimester Evaluation of Risk (FASTER) aneuploidy screening trial participants were studied from 13 centers where a 15- to 23-week genetic sonogram was performed in the same center. Midtrimester Down syndrome risks were estimated for fiv...
متن کاملScreening for Down syndrome in the second trimester of pregnancy.
Antenatal screening for fetal anomalies has provided women and their partners with information to make reproductive choices based on the risk of serious chromosomal or structural defects since the 1990s. Alternative tests include first-trimester screening (combined ultrasound and maternal serum markers), second-trimester maternal serum markers and noninvasive cell-free DNA testing. The recent r...
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ژورنال
عنوان ژورنال: Taiwanese Journal of Obstetrics and Gynecology
سال: 2008
ISSN: 1028-4559
DOI: 10.1016/s1028-4559(09)60026-7